Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression

Lens epithelial cells differentiate into lens fibers (LFs) in response to a fibroblast growth factor (FGF) gradient. This cell fate decision requires the transcription factor Prox1, which has been hypothesized to promote cell cycle exit in differentiating LF cells. However, we find that conditional...

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Detaylı Bibliyografya
Yayımlandı:Development
Asıl Yazarlar: Audette, Dylan S., Anand, Deepti, So, Tammy, Rubenstein, Troy B., Lachke, Salil A., Lovicu, Frank J., Duncan, Melinda K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725344/
https://ncbi.nlm.nih.gov/pubmed/26657765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.127860
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