Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression

Lens epithelial cells differentiate into lens fibers (LFs) in response to a fibroblast growth factor (FGF) gradient. This cell fate decision requires the transcription factor Prox1, which has been hypothesized to promote cell cycle exit in differentiating LF cells. However, we find that conditional...

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Udgivet i:Development
Main Authors: Audette, Dylan S., Anand, Deepti, So, Tammy, Rubenstein, Troy B., Lachke, Salil A., Lovicu, Frank J., Duncan, Melinda K.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725344/
https://ncbi.nlm.nih.gov/pubmed/26657765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.127860
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