Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression

Lens epithelial cells differentiate into lens fibers (LFs) in response to a fibroblast growth factor (FGF) gradient. This cell fate decision requires the transcription factor Prox1, which has been hypothesized to promote cell cycle exit in differentiating LF cells. However, we find that conditional...

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Bibliografski detalji
Izdano u:Development
Glavni autori: Audette, Dylan S., Anand, Deepti, So, Tammy, Rubenstein, Troy B., Lachke, Salil A., Lovicu, Frank J., Duncan, Melinda K.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725344/
https://ncbi.nlm.nih.gov/pubmed/26657765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.127860
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