Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

Histone acetylation is a critical process in the regulation of chromatin structure and gene expression. Histone deacetylases (HDACs) remove the acetyl group, leading to chromatin condensation and transcriptional repression. HDAC inhibitors are considered a new class of anticancer agents and have bee...

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Bibliographic Details
Published in:Acta Pharm Sin B
Main Authors: Chen, Danqi, Shen, Aijun, Fang, Guanghua, Liu, Hongchun, Zhang, Minmin, Tang, Shuai, Xiong, Bing, Ma, Lanping, Geng, Meiyu, Shen, Jingkang
Format: Artigo
Language:Inglês
Published: Elsevier 2016
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724696/
https://ncbi.nlm.nih.gov/pubmed/26904403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2015.11.002
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