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Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer
Histone acetylation is a critical process in the regulation of chromatin structure and gene expression. Histone deacetylases (HDACs) remove the acetyl group, leading to chromatin condensation and transcriptional repression. HDAC inhibitors are considered a new class of anticancer agents and have bee...
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| Publicado no: | Acta Pharm Sin B |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4724696/ https://ncbi.nlm.nih.gov/pubmed/26904403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2015.11.002 |
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