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Histone Deacetylase Inhibitors through Click Chemistry
Histone deacetylase inhibitors (HDACi) are a relatively new class of chemotherapy agents. Herein, we report a click-chemistry based approach to the synthesis of HDACi. Fourteen agents were synthesized from the combination of two alkyne and seven azido precursors. The inhibition of HDAC1 and HDAC8 wa...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3441833/ https://ncbi.nlm.nih.gov/pubmed/19007204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8005355 |
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