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Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly

To find histone deacetylase 3 (HDAC3)-selective inhibitors, a series of 504 candidates was assembled using “click chemistry”, by reacting nine alkynes bearing a zinc-binding group with 56 azide building blocks in the presence of Cu(I) catalyst. Screening of the 504-member triazole library against HD...

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Detalhes bibliográficos
Main Authors: Suzuki, Takayoshi, Kasuya, Yuki, Itoh, Yukihiro, Ota, Yosuke, Zhan, Peng, Asamitsu, Kaori, Nakagawa, Hidehiko, Okamoto, Takashi, Miyata, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713009/
https://ncbi.nlm.nih.gov/pubmed/23874714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068669
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