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Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures

Lysine-specific demethylase 1 (LSD1) mainly removes methyl groups of mono- or di-methylated lysine residues at the fourth position of histone H3 to epigenetically regulate the expression of genes associated with several diseases, such as cancer. Therefore, LSD1 inactivators are expected to be used a...

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Bibliografski detalji
Izdano u:Molecules
Glavni autori: Ota, Yosuke, Kakizawa, Taeko, Itoh, Yukihiro, Suzuki, Takayoshi
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099693/
https://ncbi.nlm.nih.gov/pubmed/29734782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23051099
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