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Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures

Lysine-specific demethylase 1 (LSD1) mainly removes methyl groups of mono- or di-methylated lysine residues at the fourth position of histone H3 to epigenetically regulate the expression of genes associated with several diseases, such as cancer. Therefore, LSD1 inactivators are expected to be used a...

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Publicat a:Molecules
Autors principals: Ota, Yosuke, Kakizawa, Taeko, Itoh, Yukihiro, Suzuki, Takayoshi
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099693/
https://ncbi.nlm.nih.gov/pubmed/29734782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23051099
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