Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease

β-Amyloid precursor protein (APP) and its cleaved products are strongly implicated in Alzheimer's disease (AD). Endosomes are highly active APP processing sites, and endosome anomalies associated with upregulated expression of early endosomal regulator, rab5, are the earliest known disease-spec...

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Detalles Bibliográficos
Publicado en:Mol Psychiatry
Main Authors: Kim, S, Sato, Y, Mohan, P S, Peterhoff, C, Pensalfini, A, Rigoglioso, A, Jiang, Y, Nixon, R A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721948/
https://ncbi.nlm.nih.gov/pubmed/26194181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.97
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