DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Cancer susceptibility genes have been classified into two groups: gatekeepers and caretakers(1). Gatekeepers are genes that control cell proliferation and death, whereas caretakers are DNA repair genes whose inactivation leads to genetic instability. Abrogation of both caretaker and gatekeeper funct...

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Bibliographic Details
Published in:Nature
Main Authors: Difilippantonio, Michael J., Zhu, Jie, Chen, Hua Tang, Meffre, Eric, Nussenzweig, Michel C., Max, Edward E., Ried, Thomas, Nussenzweig, André
Format: Artigo
Language:Inglês
Published: 2000
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721590/
https://ncbi.nlm.nih.gov/pubmed/10761921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/35006670
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