Ku80 is required for immunoglobulin isotype switching.

Isotype switching is the DNA recombination mechanism by which antibody genes diversify immunoglobulin effector functions. In contrast to V(D)J recombination, which is mediated by RAG1, RAG2 and DNA double-stranded break (DSB) repair proteins, little is known about the mechanism of switching. We have...

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Dettagli Bibliografici
Autori principali: Casellas, R, Nussenzweig, A, Wuerffel, R, Pelanda, R, Reichlin, A, Suh, H, Qin, X F, Besmer, E, Kenter, A, Rajewsky, K, Nussenzweig, M C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170583/
https://ncbi.nlm.nih.gov/pubmed/9545251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.8.2404
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