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Origin of immunoglobulin isotype switching

BACKGROUND: From humans to frogs, immunoglobulin class switching introduces different effector functions to antibodies through an intrachromsomal DNA recombination process at the heavy chain locus. Although there are two conventional antibody classes (IgM, IgW) in sharks, their heavy chains are enco...

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Detalhes bibliográficos
Main Authors: Zhu, Catherine, Lee, Victor, Finn, Alyssa, Senger, Kate, Zarrin, Ali A., Pasquier, Louis Du, Hsu, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360817/
https://ncbi.nlm.nih.gov/pubmed/22542103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.03.060
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