Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching

Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is a late B cell process that involves intrachromosomal DNA rearrangement. Ku70 and Ku80 form a DNA end-binding complex required for DNA double strand break repair and V(D)J recombination. Ku70(−/−) (K70T) mice, like recombination...

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Bibliografiske detaljer
Main Authors: Manis, John P., Gu, Yansong, Lansford, Rusty, Sonoda, Eiichiro, Ferrini, Roger, Davidson, Laurie, Rajewsky, Klaus, Alt, Frederick W.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1998
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212369/
https://ncbi.nlm.nih.gov/pubmed/9625768
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