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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Cancer susceptibility genes have been classified into two groups: gatekeepers and caretakers(1). Gatekeepers are genes that control cell proliferation and death, whereas caretakers are DNA repair genes whose inactivation leads to genetic instability. Abrogation of both caretaker and gatekeeper funct...

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Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Difilippantonio, Michael J., Zhu, Jie, Chen, Hua Tang, Meffre, Eric, Nussenzweig, Michel C., Max, Edward E., Ried, Thomas, Nussenzweig, André
Format: Artigo
Langue:Inglês
Publié: 2000
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721590/
https://ncbi.nlm.nih.gov/pubmed/10761921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/35006670
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