Formation and maintenance of Alzheimer’s disease β-amyloid plaques in the absence of microglia

In Alzheimer’s disease, microglia cluster around β-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was ac...

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Publicado en:Nat Neurosci
Autores principales: Grathwohl, Stefan A, Kälin, Roland E, Bolmont, Tristan, Prokop, Stefan, Winkelmann, Georg, Kaeser, Stephan A, Odenthal, Jörg, Radde, Rebecca, Eldh, Therese, Gandy, Sam, Aguzzi, Adriano, Staufenbiel, Matthias, Mathews, Paul M, Wolburg, Hartwig, Heppner, Frank L, Jucker, Mathias
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721582/
https://ncbi.nlm.nih.gov/pubmed/19838177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2432
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