Formation and maintenance of Alzheimer’s disease β-amyloid plaques in the absence of microglia

In Alzheimer’s disease, microglia cluster around β-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was ac...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Grathwohl, Stefan A, Kälin, Roland E, Bolmont, Tristan, Prokop, Stefan, Winkelmann, Georg, Kaeser, Stephan A, Odenthal, Jörg, Radde, Rebecca, Eldh, Therese, Gandy, Sam, Aguzzi, Adriano, Staufenbiel, Matthias, Mathews, Paul M, Wolburg, Hartwig, Heppner, Frank L, Jucker, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721582/
https://ncbi.nlm.nih.gov/pubmed/19838177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2432
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