Formation and maintenance of Alzheimer’s disease β-amyloid plaques in the absence of microglia

In Alzheimer’s disease, microglia cluster around β-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was ac...

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Publicat a:Nat Neurosci
Autors principals: Grathwohl, Stefan A, Kälin, Roland E, Bolmont, Tristan, Prokop, Stefan, Winkelmann, Georg, Kaeser, Stephan A, Odenthal, Jörg, Radde, Rebecca, Eldh, Therese, Gandy, Sam, Aguzzi, Adriano, Staufenbiel, Matthias, Mathews, Paul M, Wolburg, Hartwig, Heppner, Frank L, Jucker, Mathias
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721582/
https://ncbi.nlm.nih.gov/pubmed/19838177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2432
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