Biochemical establishment and characterization of EncM's flavin-N5-oxide cofactor

The ubiquitous flavin-dependent monooxygenases commonly catalyze oxygenation reactions by means of a transient C4a-peroxyflavin. A recent study, however, suggested an unprecedented flavin-oxygenating species - proposed as the flavin-N5-oxide (Fl(N5[O])) - as key to an oxidative Favorskii-type rearra...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Teufel, Robin, Stull, Frederick, Meehan, Michael J., Michaudel, Quentin, Dorrestein, Pieter C., Palfey, Bruce, Moore, Bradley S.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720136/
https://ncbi.nlm.nih.gov/pubmed/26067765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b03983
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