p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells

The restoration of p53 has been suggested as a therapeutic approach in tumors. However, the timing of p53 restoration in relation to its efficacy during tumor progression still is unclear. We now show that the restoration of p53 in murine premalignant proliferating pineal lesions resulted in cellula...

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Publicat a:Mol Cell Biol
Autors principals: Harajly, Mohamad, Zalzali, Hasan, Nawaz, Zafar, Ghayad, Sandra E., Ghamloush, Farah, Basma, Hussein, Zainedin, Samiha, Rabeh, Wissam, Jabbour, Mark, Tawil, Ayman, Badro, Danielle A., Evan, Gerard I., Saab, Raya
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719431/
https://ncbi.nlm.nih.gov/pubmed/26598601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00747-15
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