Temporally distinct roles for tumor suppressor pathways in cell cycle arrest and cellular senescence in Cyclin D1-driven tumor

BACKGROUND: Cellular senescence represents a tumor suppressive response to a variety of aberrant and oncogenic insults. We have previously described a transgenic mouse model of Cyclin D1-driven senescence in pineal cells that opposes tumor progression. We now attempted to define the molecular mechan...

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Autori principali: Zalzali, Hasan, Harajly, Mohamad, Abdul-Latif, Lina, El-Chaar, Nader, Dbaibo, Ghassan, Skapek, Stephen X, Saab, Raya
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497584/
https://ncbi.nlm.nih.gov/pubmed/22548705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-28
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