p18(Ink4c)and p53 act as tumor suppressors in Cyclin D1-driven primitive neuroectodermal tumor

The RB tumor suppressor pathway is likely important in primitive neuroectodermal tumors (PNET) of the brain. In fact, 10-15% of children born with RB mutations develop brain PNETs, commonly in the pineal gland. Cyclin D1, which in association with Cyclin-dependent kinases (Cdk) 4 and 6 phosphorylate...

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Autori principali: Saab, Raya, Rodriguez-Galindo, Carlos, Matmati, Kelly, Rehg, Jerold E., Baumer, Shannon H., Khoury, Joseph D., Billups, Catherine, Neale, Geoffrey, Helton, Kathleen J., Skapek, Stephen X.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629408/
https://ncbi.nlm.nih.gov/pubmed/19147556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1892
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