The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The alveolar subtype (ARMS) is clinically more aggressive, and characterized by an oncogenic fusion protein PAX3-FOXO1 that drives oncogenic cellular properties. Exosomes are small, secreted vesicles that affect paracrine sig...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ghamloush, Farah, Ghayad, Sandra E., Rammal, Ghina, Fahs, Assil, Ayoub, Abeer J., Merabi, Zeina, Harajly, Mohamad, Zalzali, Hassan, Saab, Raya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775163/
https://ncbi.nlm.nih.gov/pubmed/31578374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50592-4
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