Polyclonal CD4(+) T cell tolerance is established by distinct mechanisms, according to self-peptide expression patterns

Studies of mouse monoclonal CD4(+) T cell repertoires have revealed several mechanisms of self-tolerance, however, which mechanisms operate in normal repertoires is unclear. Here, polyclonal CD4(+) T cells specific for green fluorescent protein expressed in different organs were studied, allowing de...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Malhotra, Deepali, Linehan, Jonathan L., Dileepan, Thamotharampillai, Lee, You Jeong, Purtha, Whitney E., Lu, Jennifer V., Nelson, Ryan W., Fife, Brian T., Orr, Harry T., Anderson, Mark S., Hogquist, Kristin A., Jenkins, Marc K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718891/
https://ncbi.nlm.nih.gov/pubmed/26726812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3327
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