Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b(+) dendritic cells

Intranasal (i.n.) infections preferentially generate Th17 cells. We explored the basis for this anatomic preference by tracking polyclonal CD4(+) T cells specific for an MHC class II-bound peptide from the mucosal pathogen Streptococcus pyogenes. S. pyogenes MHC class II-bound peptide-specific CD4(+...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Linehan, Jonathan L., Dileepan, Thamotharampillai, Kashem, Sakeen W., Kaplan, Daniel H., Cleary, Patrick, Jenkins, Marc K.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611596/
https://ncbi.nlm.nih.gov/pubmed/26417101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513532112
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