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T-Cell Tolerance: Central and Peripheral
Somatic recombination of TCR genes in immature thymocytes results in some cells with useful TCR specificities, but also many with useless or potentially self-reactive specificities. Thus thymic selection mechanisms operate to shape the T-cell repertoire. Thymocytes that have a TCR with low affinity...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367546/ https://ncbi.nlm.nih.gov/pubmed/22661634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a006957 |
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