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Control of Central and Peripheral Tolerance by Aire
The negative selection of self-reactive thymocytes depends on the induction of tissue-specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even one Aire-induced tissue-specific antigen...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093413/ https://ncbi.nlm.nih.gov/pubmed/21488892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-065X.2011.01008.x |
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