Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation

Sterol regulatory element binding protein-1c (SREBP-1c) is a key transcription factor that regulates genes involved in the de novo lipid synthesis and glycolysis pathways. The structure, turnover and transactivation potential of SREBP-1c are regulated by macronutrients and hormones via a cascade of...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Dong, Qingming, Giorgianni, Francesco, Beranova-Giorgianni, Sarka, Deng, Xiong, O'Meally, Robert N., Bridges, Dave, Park, Edwards A., Cole, Robert N., Elam, Marshall B., Raghow, Rajendra
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2016
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718510/
https://ncbi.nlm.nih.gov/pubmed/26589965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150234
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