Insulin Enhances the Biogenesis of Nuclear Sterol Regulatory Element-binding Protein (SREBP)-1c by Posttranscriptional Down-regulation of Insig-2A and Its Dissociation from SREBP Cleavage-activating Protein (SCAP)·SREBP-1c Complex

The regulation of lipid homeostasis by insulin is mediated in part by the enhanced transcription of the gene encoding sterol regulatory element-binding protein-1c (SREBP-1c). The nascent SREBP-1c is embedded in the endoplasmic reticulum (ER) and must be transported to the Golgi where two sequential...

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Bibliographic Details
Main Authors: Yellaturu, Chandrahasa R., Deng, Xiong, Park, Edwards A., Raghow, Rajendra, Elam, Marshall B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797243/
https://ncbi.nlm.nih.gov/pubmed/19759400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.050914
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