Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles

The regulation of lipid homeostasis by insulin is mediated in part by the enhanced transcription of the gene encoding SREBP-1c (sterol regulatory element-binding protein-1c). Nascent SREBP-1c is synthesized and embedded in the endoplasmic reticulum (ER) and must be transported to the Golgi in coatom...

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Bibliographic Details
Main Authors: Yellaturu, Chandrahasa R., Deng, Xiong, Cagen, Lauren M., Wilcox, Henry G., Mansbach, Charles M., Siddiqi, Shadab A., Park, Edwards A., Raghow, Rajendra, Elam, Marshall B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658047/
https://ncbi.nlm.nih.gov/pubmed/19158095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805746200
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