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Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols

We report the isolation and characterization of a new line of mutant Chinese hamster ovary cells, designated SRD-5, that are resistant to 25HC, a potent suppressor of cleavage of sterol regulatory element-binding proteins (SREBPs) in mammalian cells. In SRD-5 cells, SREBPs are cleaved constitutively...

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Hlavní autoři: Yabe, Daisuke, Xia, Zong-Ping, Adams, Christopher M., Rawson, Robert B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC139202/
https://ncbi.nlm.nih.gov/pubmed/12482938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262669399
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