Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols

Eitemau Tebyg

• Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
  gan: Sun, Li-Ping, et al.
  Cyhoeddwyd: (2007)
• Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
  gan: Yabe, Daisuke, et al.
  Cyhoeddwyd: (2002)
• Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER
  gan: Espenshade, Peter J., et al.
  Cyhoeddwyd: (2002)
• Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)
  gan: Shao, Wei, et al.
  Cyhoeddwyd: (2014)
• Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi
  gan: Nohturfft, Axel, et al.
  Cyhoeddwyd: (1999)