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Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols

We report the isolation and characterization of a new line of mutant Chinese hamster ovary cells, designated SRD-5, that are resistant to 25HC, a potent suppressor of cleavage of sterol regulatory element-binding proteins (SREBPs) in mammalian cells. In SRD-5 cells, SREBPs are cleaved constitutively...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yabe, Daisuke, Xia, Zong-Ping, Adams, Christopher M., Rawson, Robert B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139202/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12482938/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.262669399
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