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Phosphorylation of Sterol Regulatory Element Binding Protein-1a by Protein Kinase A (PKA) Regulates Transcriptional Activity

The counter-regulatory hormone glucagon inhibits lipogenesis via downregulation of sterol regulatory element binding protein 1 (SREBP-1). The effect of glucagon is mediated via protein kinase A (PKA). To determine if SREBP-1 is a direct phosphorylation target of PKA, we conducted mass spectrometry a...

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書誌詳細
出版年:Biochem Biophys Res Commun
主要な著者: Dong, Qingming, Giorgianni, Francesco, Deng, Xiong, Beranova-Giorgianni, Sarka, Bridges, Dave, Park, Edwards A., Raghow, Rajendra, Elam, Marshall B.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670028/
https://ncbi.nlm.nih.gov/pubmed/24853806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.05.046
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