Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

BRAF inhibitors can extend progression‐free and overall survival in melanoma patients whose tumors harbor mutations in BRAF. However, the majority of patients eventually develop resistance to these drugs. Here we show that BRAF mutant melanoma cells that have developed acquired resistance to BRAF in...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Baenke, Franziska, Chaneton, Barbara, Smith, Matthew, Van Den Broek, Niels, Hogan, Kate, Tang, Haoran, Viros, Amaya, Martin, Matthew, Galbraith, Laura, Girotti, Maria R., Dhomen, Nathalie, Gottlieb, Eyal, Marais, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717845/
https://ncbi.nlm.nih.gov/pubmed/26365896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.08.003
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