Synthesis and Evaluation of 2,6-Modified Purine 2′-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

[Image: see text] A variety of 2,6-modified purine 2′-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation stud...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Zhou, Longhu, Zhang, Hongwang, Tao, Sijia, Ehteshami, Maryam, Cho, Jong Hyun, McBrayer, Tamara R., Tharnish, Philip, Whitaker, Tony, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716611/
https://ncbi.nlm.nih.gov/pubmed/26819659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00402
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