Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors

[Image: see text] Potent and selective class IIa HDAC tetrasubstituted cyclopropane hydroxamic acid inhibitors were identified with high oral bioavailability that exhibited good brain and muscle exposure. Compound 14 displayed suitable properties for assessment of the impact of class IIa HDAC cataly...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Luckhurst, Christopher A., Breccia, Perla, Stott, Andrew J., Aziz, Omar, Birch, Helen L., Bürli, Roland W., Hughes, Samantha J., Jarvis, Rebecca E., Lamers, Marieke, Leonard, Philip M., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2015
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716601/
https://ncbi.nlm.nih.gov/pubmed/26819662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00302
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