Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors

[Image: see text] Potent and selective class IIa HDAC tetrasubstituted cyclopropane hydroxamic acid inhibitors were identified with high oral bioavailability that exhibited good brain and muscle exposure. Compound 14 displayed suitable properties for assessment of the impact of class IIa HDAC cataly...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Luckhurst, Christopher A., Breccia, Perla, Stott, Andrew J., Aziz, Omar, Birch, Helen L., Bürli, Roland W., Hughes, Samantha J., Jarvis, Rebecca E., Lamers, Marieke, Leonard, Philip M., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716601/
https://ncbi.nlm.nih.gov/pubmed/26819662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00302
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