Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

Histone deacetylases (HDACs) are protein deacetylases that play a role in repression of gene transcription and are emerging targets in cancer therapy. Here, we characterize the structure and enzymatic activity of the catalytic domain of human HDAC7 (cdHDAC7). Although HDAC7 normally exists as part o...

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Hauptverfasser: Schuetz, Anja, Min, Jinrong, Allali-Hassani, Abdellah, Schapira, Matthieu, Shuen, Michael, Loppnau, Peter, Mazitschek, Ralph, Kwiatkowski, Nick P., Lewis, Timothy A., Maglathin, Rebecca L., McLean, Thomas H., Bochkarev, Alexey, Plotnikov, Alexander N., Vedadi, Masoud, Arrowsmith, Cheryl H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431080/
https://ncbi.nlm.nih.gov/pubmed/18285338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707362200
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