Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

Histone deacetylases (HDACs) are protein deacetylases that play a role in repression of gene transcription and are emerging targets in cancer therapy. Here, we characterize the structure and enzymatic activity of the catalytic domain of human HDAC7 (cdHDAC7). Although HDAC7 normally exists as part o...

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Main Authors: Schuetz, Anja, Min, Jinrong, Allali-Hassani, Abdellah, Schapira, Matthieu, Shuen, Michael, Loppnau, Peter, Mazitschek, Ralph, Kwiatkowski, Nick P., Lewis, Timothy A., Maglathin, Rebecca L., McLean, Thomas H., Bochkarev, Alexey, Plotnikov, Alexander N., Vedadi, Masoud, Arrowsmith, Cheryl H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2008
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431080/
https://ncbi.nlm.nih.gov/pubmed/18285338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707362200
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