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Role of HLA Adaptation in HIV Evolution

Killing of HIV-infected cells by CD8(+) T-cells imposes strong selection pressure on the virus toward escape. The HLA class I molecules that are successful in mediating some degree of control over the virus are those that tend to present epitopes in conserved regions of the proteome, such as in p24...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kløverpris, Henrik N., Leslie, Alasdair, Goulder, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716577/
https://ncbi.nlm.nih.gov/pubmed/26834742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00665
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