Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children

Pediatric slow progressors (PSP) are rare ART-naïve, HIV-infected children who maintain high CD4 T-cell counts and low immune activation despite persistently high viral loads. Using a well-defined cohort of PSP, we investigated the role of regulatory T-cells (T(REG)) and of IL-7 homeostatic signalin...

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Bibliografiska uppgifter
I publikationen:Front Immunol
Huvudupphovsmän: Roider, Julia, Ngoepe, Abigail, Muenchhoff, Maximilian, Adland, Emily, Groll, Andreas, Ndung'u, Thumbi, Kløverpris, Henrik, Goulder, Philip, Leslie, Alasdair
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2019
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379343/
https://ncbi.nlm.nih.gov/pubmed/30809229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00213
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