High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults

Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infection, since potent bnAbs develop with greater freque...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Roider, Julia, Maehara, Takashi, Ngoepe, Abigail, Ramsuran, Duran, Muenchhoff, Maximilian, Adland, Emily, Aicher, Toby, Kazer, Samuel W., Jooste, Pieter, Karim, Farina, Kuhn, Warren, Shalek, Alex K., Ndung'u, Thumbi, Morris, Lynn, Moore, Penny L., Pillai, Shiv, Kløverpris, Henrik, Goulder, Philip, Leslie, Alasdair
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143653/
https://ncbi.nlm.nih.gov/pubmed/30258437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01975
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