Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase and its dysregulation is implicated in neurodegenerative diseases. Likewise, C-terminus of Hsc70-interacting protein (CHIP) is linked to neurological disorders, serving as an E3 ubiquitin ligase for targeting damaged or t...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Kim, C, Yun, N, Lee, J, Youdim, M B H, Ju, C, Kim, W-K, Han, P-L, Oh, Y J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716296/
https://ncbi.nlm.nih.gov/pubmed/26206088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.103
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