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Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase and its dysregulation is implicated in neurodegenerative diseases. Likewise, C-terminus of Hsc70-interacting protein (CHIP) is linked to neurological disorders, serving as an E3 ubiquitin ligase for targeting damaged or t...
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| Publicado no: | Cell Death Differ |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4716296/ https://ncbi.nlm.nih.gov/pubmed/26206088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.103 |
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