CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death

Defects in mitochondrial fission and cyclin dependent kinase 5 (CDK5) activation are early events that precede neuronal loss following NMDA-induced neuronal death. Here, we report that the cytoplasmic CDK5 tightly regulates mitochondrial morphology defects associated with NMDA-induced neuronal injur...

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Bibliografiske detaljer
Udgivet i:Hum Mol Genet
Main Authors: Jahani-Asl, Arezu, Huang, En, Irrcher, Isabella, Rashidian, Juliet, Ishihara, Naotada, Lagace, Diane C., Slack, Ruth S., Park, David S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512627/
https://ncbi.nlm.nih.gov/pubmed/26002103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv188
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