Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke

CDK5 activation promotes ischemic neuronal death in stroke, with the recognized activation mechanism being calpain-dependent p35 cleavage to p25. Here we reported that CDK5-Tyr15 phosphorylation by zinc induced CDK5 activation in brain ischemic injury. CDK5 activation and CDK5-Tyr15 phosphorylation...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Tuo, Qing-Zhang, Liuyang, Zhen-Yu, Lei, Peng, Yan, Xiong, Shentu, Yang-Ping, Liang, Jia-Wei, Zhou, Huan, Pei, Lei, Xiong, Yan, Hou, Tong-Yao, Zhou, Xin-Wen, Wang, Qun, Wang, Jian-Zhi, Wang, Xiao-Chuan, Liu, Rong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115431/
https://ncbi.nlm.nih.gov/pubmed/30158515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0929-7
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