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Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death
The phosphatidylinositol-3-kinase-like kinase ATM (Ataxia – telangiectasia mutated) plays a central role in coordinating the DNA damage responses including cell cycle checkpoint control, DNA repair, and apoptosis. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760486/ https://ncbi.nlm.nih.gov/pubmed/19151707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1829 |
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