Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

Apoptosis inducing factor (AIF) is a mitochondrial oxidoreductase that scavenges reactive oxygen species under normal conditions. Under certain stresses, such as exposure to N-methyl-N′-nitro-N′-nitrosoguanidine (MNNG), AIF is truncated and released from the mitochondria and translocated into the nu...

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Autori principali: Oh, K H, Yang, S W, Park, J M, Seol, J H, Iemura, S, Natsume, T, Murata, S, Tanaka, K, Jeon, Y J, Chung, C H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172096/
https://ncbi.nlm.nih.gov/pubmed/21293491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.3
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