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Amino acid positions subject to multiple co-evolutionary constraints can be robustly identified by their eigenvector network centrality scores
As proteins evolve, amino acid positions key to protein structure or function are subject to mutational constraints. These positions can be detected by analyzing sequence families for amino acid conservation or for co-evolution between pairs of positions. Co-evolutionary scores are usually rank-orde...
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| 出版年: | Proteins |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4715571/ https://ncbi.nlm.nih.gov/pubmed/26503808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24948 |
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