EVIDENCE OF THE IMPORTANCE OF NOX4 IN PRODUCTION OF HYPERTENSION IN DAHL SALT-SENSITIVE RATS

This study reports the consequences of knocking out NADPH oxidase 4 (Nox4) upon the development of hypertension and kidney injury in the Dahl salt-sensitive (SS) rat. Zinc finger nuclease injection of single cell SS embryos was used to create an 8 base-pair frame-shift deletion of Nox4 resulting in...

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Publicado en:Hypertension
Autores principales: Cowley, Allen W., Yang, Chun, Zheleznova, Nadezhda N., Staruschenko, Alexander, Kurth, Theresa, Rein, Lisa, Kumar, Vikash, Sadovnikov, Katherine, Dayton, Alex, Hoffman, Matthew, Ryan, Robert P., Skelton, Meredith M., Salehpour, Fahimeh, Ranji, Mahsa, Geurts, Aron
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713301/
https://ncbi.nlm.nih.gov/pubmed/26644237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06280
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