Therapeutic Suppression of mTOR Signaling Prevents and Reverses Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats

Mammalian target of rapamycin (mTOR) signaling has emerged as a key regulator in a wide range of cellular processes ranging from cell proliferation, immune responses, and electrolyte homeostasis. mTOR consists of two distinct protein complexes mTORC1 and mTORC2, each with distinct downstream signali...

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Publicado en:Hypertension
Main Authors: Kumar, Vikash, Evans, Louise C., Kurth, Theresa, Yang, Chun, Wollner, Clayton, Nasci, Victoria, Zheleznova, Nadezhda N., Bukowy, John, Dayton, Alex, Cowley, Allen W.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374175/
https://ncbi.nlm.nih.gov/pubmed/30595123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12378
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