EVIDENCE OF THE IMPORTANCE OF NOX4 IN PRODUCTION OF HYPERTENSION IN DAHL SALT-SENSITIVE RATS

This study reports the consequences of knocking out NADPH oxidase 4 (Nox4) upon the development of hypertension and kidney injury in the Dahl salt-sensitive (SS) rat. Zinc finger nuclease injection of single cell SS embryos was used to create an 8 base-pair frame-shift deletion of Nox4 resulting in...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Cowley, Allen W., Yang, Chun, Zheleznova, Nadezhda N., Staruschenko, Alexander, Kurth, Theresa, Rein, Lisa, Kumar, Vikash, Sadovnikov, Katherine, Dayton, Alex, Hoffman, Matthew, Ryan, Robert P., Skelton, Meredith M., Salehpour, Fahimeh, Ranji, Mahsa, Geurts, Aron
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713301/
https://ncbi.nlm.nih.gov/pubmed/26644237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06280
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