EVIDENCE OF THE IMPORTANCE OF NOX4 IN PRODUCTION OF HYPERTENSION IN DAHL SALT-SENSITIVE RATS

This study reports the consequences of knocking out NADPH oxidase 4 (Nox4) upon the development of hypertension and kidney injury in the Dahl salt-sensitive (SS) rat. Zinc finger nuclease injection of single cell SS embryos was used to create an 8 base-pair frame-shift deletion of Nox4 resulting in...

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Pubblicato in:Hypertension
Autori principali: Cowley, Allen W., Yang, Chun, Zheleznova, Nadezhda N., Staruschenko, Alexander, Kurth, Theresa, Rein, Lisa, Kumar, Vikash, Sadovnikov, Katherine, Dayton, Alex, Hoffman, Matthew, Ryan, Robert P., Skelton, Meredith M., Salehpour, Fahimeh, Ranji, Mahsa, Geurts, Aron
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713301/
https://ncbi.nlm.nih.gov/pubmed/26644237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06280
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