EVIDENCE OF THE IMPORTANCE OF NOX4 IN PRODUCTION OF HYPERTENSION IN DAHL SALT-SENSITIVE RATS

This study reports the consequences of knocking out NADPH oxidase 4 (Nox4) upon the development of hypertension and kidney injury in the Dahl salt-sensitive (SS) rat. Zinc finger nuclease injection of single cell SS embryos was used to create an 8 base-pair frame-shift deletion of Nox4 resulting in...

詳細記述

保存先:
書誌詳細
出版年:Hypertension
主要な著者: Cowley, Allen W., Yang, Chun, Zheleznova, Nadezhda N., Staruschenko, Alexander, Kurth, Theresa, Rein, Lisa, Kumar, Vikash, Sadovnikov, Katherine, Dayton, Alex, Hoffman, Matthew, Ryan, Robert P., Skelton, Meredith M., Salehpour, Fahimeh, Ranji, Mahsa, Geurts, Aron
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713301/
https://ncbi.nlm.nih.gov/pubmed/26644237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06280
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